The Threat List

Status:Last news sweep 28 Sept 2026

The World Problems Index — Ranked in Five Measures

Every major problem in the world, measured the same way and ranked side by side.

Wars, epidemics, famines and slow collapses are usually reported separately and never compared. This index scores each one on loss of life, lives harmed, financial cost, environmental damage and trajectory, then puts them in a single ordered list. How the scores are built.

What changed in the last sweep

179 problems tracked · 2 up, 2 down, 2 revised →

The hundred most severe problems currently tracked.
96 eventsMovement · Severity 0—100
  1. 01—

    Climate Change

    Global

    Warming driven by greenhouse gas emissions is raising mortality, displacement and economic damage across every region.

    Deaths
    250 thousand
    (per year (projected))
    Impacted
    3.3 billion
    Cost
    $1.4 trillion
    Trend
    Worsening
    90.8

    Catastrophic

  2. 02—

    Russia-Ukraine War

    Eastern Europe

    The largest interstate war in Europe since 1945, with mass casualties, displacement and global food and energy shocks.

    Deaths
    1 million
    (since Feb 2022)
    Impacted
    44 million
    Cost
    $600 billion
    Trend
    Worsening
    87.6

    Catastrophic

  3. 03—

    Air Pollution

    Global

    Fine particulate and ozone pollution is one of the largest single killers on earth, concentrated in Asia and Africa.

    Deaths
    6.7 million
    (per year)
    Impacted
    9 billion
    Cost
    $8.1 trillion
    Trend
    Steady
    86.4

    Catastrophic

  4. 04—

    Global Hunger and Food Insecurity

    Global

    Hundreds of millions face chronic undernourishment; tens of millions face emergency or famine conditions.

    Deaths
    9 million
    (per year)
    Impacted
    733 million
    Cost
    $3.5 trillion
    Trend
    Worsening
    86.4

    Catastrophic

  5. 05—

    Extreme Heat

    GlobalNews-derived

    Extreme heat is a widespread and escalating global health, economic, and environmental hazard. The supplied evidence documents substantial mortality, lost labor productivity, health costs, and agricultural losses, with impacts expected to worsen as temperatures rise.

    Deaths
    10 thousand
    Impacted
    —
    Cost
    $16 trillion
    Trend
    Steady
    85.1

    Catastrophic

  6. 06—

    Human Cost of Post-9/11 US-Led Wars

    Middle East, South Asia and AfricaNews-derived

    Retrospective estimates attribute millions of deaths, tens of millions displaced and trillions spent to post-9/11 wars.

    Deaths
    —
    Impacted
    —
    Cost
    —
    Trend
    Steady
    82.1

    Catastrophic

  7. 07—

    Gaza War

    Middle East

    Intense urban warfare has killed tens of thousands and displaced nearly the whole population of the Gaza Strip.

    Deaths
    75 thousand
    (since Oct 2023)
    Impacted
    2.2 million
    Cost
    $50 billion
    Trend
    Worsening
    81.8

    Catastrophic

  8. 08—

    Sudan Civil War

    East Africa

    Fighting between the army and the RSF has produced the world's largest displacement and hunger crisis.

    Deaths
    200 thousand
    (since Apr 2023)
    Impacted
    34 million
    Cost
    $30 billion
    Trend
    Worsening
    80.1

    Catastrophic

  9. 09—

    Drought

    GlobalNews-derived

    Drought is a widespread, recurrent hazard that causes water shortages, crop failures, hunger, livelihood losses and ecosystem degradation. The supplied evidence indicates very high historical mortality and substantial economic harm, although it does not establish a single global event total or current-year estimate.

    Deaths
    —
    Impacted
    55 million
    Cost
    $249 billion
    Trend
    Steady
    77.9

    Critical

  10. 10—

    Dirty Cooking Fuel

    Global, especially low- and middle-income countries and AfricaNews-derived

    Reliance on polluting fuels and inefficient stoves exposes more than two billion people to household air pollution, causing an estimated 2.9 million deaths annually and imposing major health, productivity, and climate costs.

    Deaths
    2.9 million
    Impacted
    2 billion
    Cost
    $2.4 trillion
    Trend
    Steady
    76.7

    Critical

  11. 11—

    Antimicrobial Resistance

    Global

    Drug-resistant infections already kill more than HIV or malaria and are projected to accelerate sharply.

    Deaths
    1.3 million
    (per year)
    Impacted
    9 billion
    Cost
    $1 trillion
    Trend
    Worsening
    76.3

    Critical

  12. 12—

    Lack of Surgical Access

    Global, especially low- and middle-income countriesNews-derived

    A global health-system failure in which an estimated 5 billion people lack access to safe, timely, and affordable surgical and anesthesia care, causing substantial preventable mortality, catastrophic household spending, and long-term productivity losses.

    Deaths
    1.5 million
    Impacted
    5 billion
    Cost
    $12 trillion
    Trend
    Steady
    75.5

    Critical

  13. 13—

    Eastern DRC Conflict

    Central Africa

    Decades of overlapping armed conflict in a mineral-rich region, with mass displacement and one of the highest excess-death tolls of the modern era.

    Deaths
    6 million
    (since 1996)
    Impacted
    25 million
    Cost
    $30 billion
    Trend
    Worsening
    74.3

    Critical

  14. 14—

    Unsafe Water and Sanitation

    Global

    Billions lack safely managed water or sanitation, driving preventable disease deaths concentrated in children.

    Deaths
    1.4 million
    (per year)
    Impacted
    3.5 billion
    Cost
    $260 billion
    Trend
    Improving
    73.7

    Critical

  15. 15—

    Road Traffic Injuries

    Global

    Road crashes are the leading killer of young people worldwide and a top-ten cause of death overall.

    Deaths
    1.2 million
    (per year)
    Impacted
    50 million
    Cost
    $1.8 trillion
    Trend
    Steady
    73.2

    Critical

  16. 16▲1

    Lead Poisoning

    globalNews-derived

    Lead exposure is a widespread global health and environmental problem that can cause irreversible neurological injury, cardiovascular and other disease, premature death, and substantial lifetime productivity losses, especially among children.

    Deaths
    3.5 million
    Impacted
    18 thousand
    Cost
    $906 billion
    Trend
    Steady
    71.9

    Critical

  17. 17▲1

    Mental Health Crisis and Suicide

    Global

    More than 700,000 people die by suicide each year and a billion live with a mental health condition.

    Deaths
    727 thousand
    (per year)
    Impacted
    970 million
    Cost
    $1 trillion
    Trend
    Worsening
    71.9

    Critical

  18. 18▲1

    Yemen Humanitarian Crisis

    Middle East

    Years of war have left over half the population needing aid, with famine risk and collapsed health services.

    Deaths
    377 thousand
    (since 2014)
    Impacted
    22 million
    Cost
    $126 billion
    Trend
    Worsening
    71.8

    Critical

  19. 19▲1

    Cardiovascular Disease

    Global

    The single largest killer of humans, and largely preventable.

    Deaths
    20 million
    (per year)
    Impacted
    600 million
    Cost
    $1 trillion
    Trend
    Worsening
    71.1

    Critical

  20. 20▲1

    Syria Post-War Crisis

    Middle East

    Fourteen years of war left a shattered state, mass displacement and a stalled recovery.

    Deaths
    600 thousand
    (since 2011)
    Impacted
    17 million
    Cost
    $400 billion
    Trend
    Steady
    70.9

    Critical

  21. 21▲2

    Small Arms Proliferation

    GlobalNews-derived

    The widespread availability and illicit proliferation of small arms and light weapons fuels homicide, armed conflict, insecurity, displacement, and barriers to development worldwide. The cited evidence reports 260,000 small-arms deaths in 2021, representing 45% of violent deaths that year.

    Deaths
    260 thousand
    Impacted
    —
    Cost
    —
    Trend
    Steady
    70.4

    Critical

  22. 22▲2

    Sea Level Rise and Coastal Erosion

    Global

    Hundreds of millions of people live below the level the sea is heading for.

    Deaths
    —
    Impacted
    14 million
    Cost
    $14 trillion
    Trend
    Worsening
    69.1

    Critical

  23. 23▲3

    Global Cancer Burden

    Global

    The second largest cause of death worldwide, rising as populations age and screening lags in poorer countries.

    Deaths
    9.7 million
    (per year)
    Impacted
    20 million
    Cost
    $1.2 trillion
    Trend
    Worsening
    68.2

    Critical

  24. 24▲4

    Diabetes and Obesity

    Global

    A metabolic epidemic reshaping health systems in every income bracket.

    Deaths
    3.4 million
    (per year)
    Impacted
    1.8 billion
    Cost
    $1 trillion
    Trend
    Worsening
    67.7

    Critical

  25. 25▲4

    Lead Exposure

    Global

    A neurotoxin still circulating in paint, cookware, batteries and spices, costing children measurable IQ.

    Deaths
    1.5 million
    (per year)
    Impacted
    800 million
    Cost
    $6 trillion
    Trend
    Steady
    67.7

    Critical

  26. 26▲4

    Antibiotic Pipeline Failure

    GlobalNews-derived

    Insufficient development and commercialization of new antibiotics is weakening the ability to treat drug-resistant bacterial infections. The supplied evidence indicates a substantial current health and economic burden from antimicrobial resistance and warns of much larger future losses if effective antibiotics remain unavailable.

    Deaths
    4.7 million
    Impacted
    —
    Cost
    $4.6 billion
    Trend
    Steady
    67.4

    Critical

  27. 27▲4

    Invasive Species

    GlobalNews-derived

    Invasive alien species are a global environmental and economic threat that damages biodiversity, agriculture, infrastructure, and human well-being. The supplied evidence indicates very large and rising costs, including an estimated $423 billion annually worldwide.

    Deaths
    —
    Impacted
    —
    Cost
    $423 billion
    Trend
    Steady
    66.9

    Critical

  28. 28▲4

    South Sudan Crisis

    East Africa

    Political violence, flooding and economic collapse in the world youngest country.

    Deaths
    1.7 thousand
    (since 2013)
    Impacted
    7.8 million
    Cost
    —
    Trend
    Worsening
    66.9

    Critical

  29. 29▲4

    Tobacco Use

    Global

    The largest preventable cause of death on earth.

    Deaths
    8 million
    (per year)
    Impacted
    1.3 billion
    Cost
    $1.4 trillion
    Trend
    Improving
    66.8

    Critical

  30. 30▲4

    Extreme Wildfires

    Global

    Fire seasons are lengthening and burning places that historically did not burn.

    Deaths
    300 thousand
    (per year)
    Impacted
    400 million
    Cost
    $150 billion
    Trend
    Worsening
    66.7

    Critical

  31. 31▲4

    Global Forced Displacement

    Global

    Over 120 million people have been forced from their homes, the highest number ever recorded.

    Deaths
    —
    Impacted
    122 million
    Cost
    $400 billion
    Trend
    Worsening
    66.2

    Critical

  32. 32▲4

    Child Stunting and Wasting

    GlobalNews-derived

    A global public-health and nutrition problem in which children experience impaired growth from chronic undernutrition (stunting) or dangerously low weight for height from acute undernutrition (wasting), increasing illness, developmental harm, and mortality risk.

    Deaths
    2.7 million
    Impacted
    194 million
    Cost
    $135 billion
    Trend
    Steady
    66.1

    Critical

  33. 33▲5

    Intensifying Tropical Cyclones

    Global

    Storms are intensifying faster and carrying more water than the infrastructure was built for.

    Deaths
    15 thousand
    (per year)
    Impacted
    700 million
    Cost
    $150 billion
    Trend
    Worsening
    64.6

    Severe

  34. 34▲5

    Healthcare-Associated Infection

    GlobalNews-derived

    Healthcare-associated infections are a major global patient-safety and public-health problem, causing millions of infections, substantial mortality, prolonged hospitalization, and large recurring healthcare and productivity costs.

    Deaths
    500 thousand
    Impacted
    4.8 million
    Cost
    —
    Trend
    Steady
    62.4

    Severe

  35. 35▲6

    PFAS and Forever Chemicals

    Global

    Industrial chemicals that do not break down are now in almost every human bloodstream.

    Deaths
    —
    Impacted
    4 billion
    Cost
    $8 billion
    Trend
    Worsening
    62.1

    Severe

  36. 36▲6

    Transboundary Water Disputes

    GlobalNews-derived

    Disputes over shared rivers, aquifers, and other cross-border water resources threaten water security, agriculture, energy, ecosystems, livelihoods, and interstate stability. Climate change and growing demand may intensify scarcity and tensions across basins supporting much of the global population.

    Deaths
    —
    Impacted
    1.8 billion
    Cost
    —
    Trend
    Steady
    61.7

    Severe

  37. 37▲6

    Deforestation and Land Degradation

    Global

    Forest loss continues at millions of hectares per year, undermining climate stability, water cycles and food systems.

    Deaths
    —
    Impacted
    1.6 billion
    Cost
    $600 billion
    Trend
    Worsening
    61.4

    Severe

  38. 38▲6

    Freshwater and Groundwater Depletion

    Global

    Aquifers that took millennia to fill are being drained within a lifetime.

    Deaths
    —
    Impacted
    2 billion
    Cost
    $700 billion
    Trend
    Worsening
    61.2

    Severe

  39. 39▼12

    Global Natural Disaster Losses in 2025

    GlobalNews-derived

    Assessments report 16,607 disaster deaths, 110.2 million people affected and roughly $224 billion in worldwide damage during 2025.

    Deaths
    17 thousand
    Impacted
    110 million
    Cost
    —
    Trend
    Steady
    61.1

    Severe

  40. 40▲6

    Ethiopia Internal Conflicts

    East Africa

    Fighting in Amhara and Oromia continues after the Tigray war, with severe humanitarian consequences.

    Deaths
    600 thousand
    (2020-2022)
    Impacted
    21 million
    Cost
    —
    Trend
    Worsening
    60.7

    Severe

  41. 41▲7

    Household Air Pollution

    Global

    Cooking on solid fuel kills millions, almost entirely women and children.

    Deaths
    3.2 million
    (per year)
    Impacted
    2.1 billion
    Cost
    —
    Trend
    Improving
    60.3

    Severe

  42. 42▲5

    Myanmar Civil War

    Southeast Asia

    A nationwide armed resistance to military rule has produced mass displacement, airstrikes on civilians and economic collapse.

    Deaths
    75 thousand
    (since 2021)
    Impacted
    19 million
    Cost
    $20 billion
    Trend
    Worsening
    60.3

    Severe

  43. 43▲6

    Tsunami Risk

    Global coastal regionsNews-derived

    Tsunamis are infrequent but potentially catastrophic coastal disasters that can cause mass mortality, widespread displacement, infrastructure destruction, environmental damage, and major economic losses.

    Deaths
    252 thousand
    Impacted
    —
    Cost
    $280 billion
    Trend
    Steady
    59.5

    Severe

  44. 44▲8

    Soil Degradation

    Global

    A third of the world topsoil is degraded and it forms far slower than it is lost.

    Deaths
    —
    Impacted
    3.2 billion
    Cost
    $400 billion
    Trend
    Worsening
    58.6

    Severe

  45. 45▲8

    Extreme Poverty

    Global

    Around seven hundred million people live on less than the international poverty line.

    Deaths
    —
    Impacted
    700 million
    Cost
    —
    Trend
    Steady
    58.5

    Severe

  46. 46▲9

    Sahel Insurgency

    West Africa

    Jihadist insurgency and state collapse across Mali, Burkina Faso and Niger have made the Sahel the global epicentre of terrorism deaths.

    Deaths
    7.6 thousand
    (since 2012)
    Impacted
    1 million
    Cost
    $15 billion
    Trend
    Worsening
    58.4

    Severe

  47. 47▲10

    Gender-Based Violence

    Global

    The most widespread human rights violation in the world, and among the least prosecuted.

    Deaths
    50 thousand
    (per year)
    Impacted
    736 million
    Cost
    $1.5 trillion
    Trend
    Steady
    57.8

    Severe

  48. 48▲12

    Opioid and Overdose Crisis

    North America

    Synthetic opioids have driven the deadliest drug epidemic in recorded history, concentrated in North America.

    Deaths
    110 thousand
    (per year (peak))
    Impacted
    50 million
    Cost
    $1.5 trillion
    Trend
    Improving
    56.8

    Severe

  49. 49▲13

    Nigeria Insecurity and Banditry

    West Africa

    Insurgency in the northeast and armed banditry in the northwest have displaced millions.

    Deaths
    120 thousand
    (since 2009)
    Impacted
    25 million
    Cost
    —
    Trend
    Worsening
    56.5

    Severe

  50. 50▲16

    Tuberculosis

    Global

    The deadliest infectious disease in the world, curable but persistently underfunded.

    Deaths
    1.3 million
    (per year)
    Impacted
    11 million
    Cost
    $50 billion
    Trend
    Improving
    55.2

    Severe

  51. 51▲18

    Malaria

    Sub-Saharan Africa

    A preventable mosquito-borne disease that still kills a child roughly every minute.

    Deaths
    600 thousand
    (per year)
    Impacted
    263 million
    Cost
    $12 billion
    Trend
    Steady
    54.5

    Severe

  52. 52▲19

    Chronic Respiratory Disease

    Global

    Lung disease driven by smoke, dust and polluted air, concentrated in the poorest households.

    Deaths
    4 million
    (per year)
    Impacted
    545 million
    Cost
    —
    Trend
    Steady
    54.1

    Severe

  53. 53▲20

    Colombia Armed Group Violence

    South America

    Post-peace-deal fragmentation has left armed groups controlling large rural areas.

    Deaths
    450 thousand
    (since 1985)
    Impacted
    9 million
    Cost
    —
    Trend
    Worsening
    53.9

    Severe

  54. 54▲20

    Religious Persecution

    GlobalNews-derived

    Religious persecution is a global human-rights and humanitarian problem involving discrimination, repression, violence, and killings based on religious identity or belief. The supplied evidence focuses primarily on Christians and reports hundreds of millions facing high levels of persecution or discrimination.

    Deaths
    5 thousand
    Impacted
    365 million
    Cost
    —
    Trend
    Steady
    53.7

    Severe

  55. 55▲20

    Modern Slavery and Human Trafficking

    Global

    Roughly 50 million people live in forced labour or forced marriage, embedded in global supply chains.

    Deaths
    —
    Impacted
    50 million
    Cost
    $150 billion
    Trend
    Worsening
    53.3

    Severe

  56. 56▲51

    Iran War

    Iran and Middle EastNews-derived

    The U.S.-Iran conflict has killed thousands and damaged U.S. military bases across the Middle East, indicating sustained regional escalation.

    Deaths
    3.7 thousand
    Impacted
    —
    Cost
    —
    Trend
    Worsening
    52.9

    Severe

  57. 57▲22

    Alcohol-Related Harm

    Global

    Deaths, violence and disease from a substance most societies treat as unremarkable.

    Deaths
    2.6 million
    (per year)
    Impacted
    400 million
    Cost
    $800 billion
    Trend
    Steady
    52.1

    Severe

  58. 58▲22

    Somalia Conflict and Al-Shabaab Insurgency

    East Africa

    Insurgency, clan conflict and repeated drought compound one of the worst humanitarian situations on earth.

    Deaths
    2.9 thousand
    (past decade)
    Impacted
    6.9 million
    Cost
    —
    Trend
    Worsening
    51.6

    Severe

  59. 59▲39

    Haiti State Collapse

    Caribbean

    Armed gangs control most of the capital amid state failure, hunger and mass displacement.

    Deaths
    12 thousand
    (per year)
    Impacted
    5.5 million
    Cost
    $5 billion
    Trend
    Worsening
    51.1

    Severe

  60. 60▲25

    Mexico Cartel Violence

    North America

    One of the highest absolute homicide counts in the world outside a declared war.

    Deaths
    30 thousand
    (per year)
    Impacted
    115 thousand
    Cost
    $13 billion
    Trend
    Steady
    49.9

    Serious

  61. 61▲27

    HIV and AIDS

    Global

    A treatable pandemic that still kills hundreds of thousands a year because treatment reaches unevenly.

    Deaths
    630 thousand
    (per year)
    Impacted
    40 million
    Cost
    $20 billion
    Trend
    Improving
    49.5

    Serious

  62. 62▲27

    Overfishing and Fisheries Collapse

    Global

    A third of global fish stocks are harvested beyond biological limits.

    Deaths
    —
    Impacted
    600 million
    Cost
    $80 billion
    Trend
    Worsening
    49.3

    Serious

  63. 63▲28

    Learning Poverty

    Global

    Most children in poor countries cannot read a simple story by age ten.

    Deaths
    —
    Impacted
    500 million
    Cost
    $21 trillion
    Trend
    Worsening
    49.0

    Serious

  64. 64▲30

    Housing Affordability and Homelessness

    Global

    Shelter has become unaffordable across most of the urban world.

    Deaths
    —
    Impacted
    1.1 billion
    Cost
    $4 billion
    Trend
    Worsening
    48.7

    Serious

  65. 65▲28

    Venezuela Migration and Economic Crisis

    South America

    The largest displacement crisis in the Western Hemisphere.

    Deaths
    —
    Impacted
    19 million
    Cost
    —
    Trend
    Steady
    48.7

    Serious

  66. 66▲29

    Oil Spills and Gas Flaring

    GlobalNews-derived

    Oil spills contaminate marine and coastal ecosystems, while routine gas flaring releases climate-warming gases and harmful air pollutants. The supplied evidence documents substantial health burdens from U.S. flaring and broader ecological and socioeconomic harm, but does not establish a unified global toll.

    Deaths
    710
    Impacted
    500 thousand
    Cost
    $7.3 billion
    Trend
    Steady
    48.2

    Serious

  67. 67▲37

    Landmines and Unexploded Ordnance

    Global, concentrated in conflict-affected and post-conflict countriesNews-derived

    A persistent global conflict-remnant threat that kills and injures civilians, restricts land use and livelihoods, impedes refugee return, and slows post-conflict recovery across dozens of contaminated countries.

    Deaths
    —
    Impacted
    6.3 thousand
    Cost
    —
    Trend
    Steady
    45.4

    Serious

  68. 68▲40

    Viral Hepatitis

    Global

    A curable and preventable infection that still kills more people than malaria.

    Deaths
    1.3 million
    (per year)
    Impacted
    300 million
    Cost
    —
    Trend
    Worsening
    44.4

    Serious

  69. 69▲41

    Korean Peninsula Tensions

    East Asia

    A nuclear-armed standoff alongside one of the most severe closed-country humanitarian situations.

    Deaths
    —
    Impacted
    10 million
    Cost
    —
    Trend
    Worsening
    43.4

    Serious

  70. 70▲41

    Trafficked Scam Compounds

    Southeast Asia and globalNews-derived

    Organized criminal operations, concentrated in Southeast Asia but transnational in reach, traffic and coerce people into conducting online fraud, often alongside detention, violence and sexual exploitation.

    Deaths
    —
    Impacted
    300 thousand
    Cost
    $10 billion
    Trend
    Steady
    43.1

    Serious

  71. 71▲41

    Drowning

    GlobalNews-derived

    Drowning is a major global, preventable cause of injury death, disproportionately affecting low- and middle-income countries and imposing substantial social and economic costs.

    Deaths
    300 thousand
    Impacted
    856 thousand
    Cost
    —
    Trend
    Steady
    42.9

    Serious

  72. 72▲43

    Attacks on Health Facilities

    Global, especially conflict-affected countriesNews-derived

    Violence against hospitals, health workers, patients, and medical transport disrupts essential care in conflicts and emergencies. The supplied evidence reports hundreds to more than a thousand attacks annually and substantial direct casualties, but does not establish a comprehensive global impact or attributable economic cost.

    Deaths
    115
    Impacted
    —
    Cost
    —
    Trend
    Steady
    40.6

    Serious

  73. 73▲43

    Permafrost Thaw

    Arctic

    A carbon store twice the size of the atmosphere is beginning to release.

    Deaths
    —
    Impacted
    5 million
    Cost
    $70 billion
    Trend
    Worsening
    40.5

    Serious

  74. 74▲25

    Somalia Drought and Child Malnutrition Crisis

    SomaliaNews-derived

    Somalia's hunger emergency is deepening, with 1.48 million people projected to face Emergency-level food insecurity.

    Deaths
    —
    Impacted
    6.5 million
    Cost
    —
    Trend
    Worsening
    40.3

    Serious

  75. 75▲46

    Tax Avoidance

    GlobalNews-derived

    The legal or quasi-legal reduction of tax liabilities through loopholes and cross-border arrangements erodes public revenue, can weaken public services, and may worsen inequality worldwide.

    Deaths
    —
    Impacted
    —
    Cost
    $550 billion
    Trend
    Steady
    39.2

    Serious

  76. 76▲46

    Nuclear Proliferation and Escalation Risk

    Global

    Arms control has collapsed while nuclear arsenals modernise, creating the highest escalation risk in decades.

    Deaths
    0
    (potential)
    Impacted
    8 billion
    Cost
    $0
    Trend
    Worsening
    38.8

    Serious

  77. 77▲48

    Neglected Tropical Diseases

    Global

    A group of disabling infections affecting more than a billion people and attracting little funding.

    Deaths
    200 thousand
    (per year)
    Impacted
    1.6 billion
    Cost
    —
    Trend
    Improving
    38.4

    Serious

  78. 78▲48

    Child Marriage

    Global

    Twelve million girls are married before eighteen every year.

    Deaths
    22 thousand
    Impacted
    640 million
    Cost
    $175 billion
    Trend
    Improving
    38.0

    Serious

  79. 79▲51

    Long COVID

    Global

    A large, poorly measured chronic illness burden left behind by the pandemic.

    Deaths
    3.5 thousand
    Impacted
    65 million
    Cost
    $1 trillion
    Trend
    Steady
    36.6

    Serious

  80. 80▲54

    Private Military Groups

    GlobalNews-derived

    Private military groups and contractors operate in armed conflicts, creating risks to civilians, accountability, governance, and contractor personnel. The supplied evidence documents contractor deaths but does not support a global estimate of civilian harm, displacement, affected populations, economic losses, or environmental damage attributable specifically to these groups.

    Deaths
    8 thousand
    Impacted
    —
    Cost
    —
    Trend
    Steady
    35.8

    Serious

  81. 81▲56

    Kashmir Dispute

    South Asia

    A militarised territorial dispute between two nuclear-armed states.

    Deaths
    45 thousand
    (since 1989)
    Impacted
    13 million
    Cost
    —
    Trend
    Steady
    34.9

    Limited

  82. 82▲60

    Cabo Delgado Insurgency

    Southern Africa

    An Islamist insurgency in northern Mozambique sitting on top of a major gas project.

    Deaths
    6 thousand
    (since 2017)
    Impacted
    1.3 million
    Cost
    —
    Trend
    Worsening
    33.7

    Limited

  83. 83▲60

    Central African Republic Conflict

    Central Africa

    A long-running armed conflict that has displaced a fifth of the population.

    Deaths
    12 thousand
    (past decade)
    Impacted
    2.8 million
    Cost
    —
    Trend
    Steady
    33.0

    Limited

  84. 84▲62

    Migrant Route Deaths

    GlobalNews-derived

    Deaths and disappearances on dangerous migration routes constitute an ongoing global humanitarian crisis. IOM-linked results report at least 7,667 people dead or missing worldwide in 2025, with roughly 340,000 family members directly affected; longer and more dangerous journeys may be worsening risks on major routes.

    Deaths
    68 thousand
    Impacted
    340 thousand
    Cost
    —
    Trend
    Steady
    32.2

    Limited

  85. 85▲63

    Attacks on Aid Workers

    GlobalNews-derived

    Aid-worker killings reached a reported record of 383 in 2024, underscoring worsening danger to humanitarian personnel.

    Deaths
    383
    Impacted
    907
    Cost
    —
    Trend
    Worsening
    31.9

    Limited

  86. 86▲63

    Female Genital Mutilation

    Global

    A practice affecting hundreds of millions of women, and population growth is outpacing decline.

    Deaths
    —
    Impacted
    230 million
    Cost
    $1.4 billion
    Trend
    Worsening
    31.6

    Limited

  87. 87▲63

    Internet Shutdowns

    Global

    Governments switch off connectivity during exactly the moments it matters most.

    Deaths
    —
    Impacted
    700 million
    Cost
    $10 billion
    Trend
    Worsening
    30.9

    Limited

  88. 88▲64

    Avian Influenza H5N1

    GlobalNews-derived

    A globally recurring highly pathogenic avian influenza outbreak causing extensive poultry and wild-bird mortality, agricultural disruption, food-price pressure, and sporadic human infections. The supplied evidence documents tens of millions of animal losses and multibillion-dollar costs, but does not establish a supported total for human deaths, people affected, or displacement.

    Deaths
    11
    Impacted
    26
    Cost
    $3 billion
    Trend
    Steady
    30.6

    Limited

  89. 89▲65

    Western Colombia Earthquake

    Western ColombiaNews-derived

    A magnitude-7.4 earthquake in western Colombia reportedly killed hundreds and caused $9.57 billion in damage.

    Deaths
    —
    Impacted
    —
    Cost
    $9.6 billion
    Trend
    Steady
    30.0

    Limited

  90. 90▲65

    Karamoja Drought and Hunger Crisis

    Karamoja, UgandaNews-derived

    Uganda began emergency food distributions after drought and crop failures caused hunger affecting 1.5 million people and reportedly killed 19.

    Deaths
    19
    Impacted
    1.5 million
    Cost
    —
    Trend
    Worsening
    29.5

    Limited

  91. 91▲65

    Synthetic Media

    GlobalNews-derived

    AI-generated or manipulated audio, images, video, and text can enable fraud, impersonation, harassment, and disinformation, but the supplied evidence does not establish direct global casualties or a synthetic-media-specific economic loss estimate.

    Deaths
    —
    Impacted
    —
    Cost
    $1.6 billion
    Trend
    Steady
    29.1

    Limited

  92. 92▲65

    Cholera Resurgence

    Global

    A wave of outbreaks driven by conflict, floods and broken water systems.

    Deaths
    6 thousand
    (per year)
    Impacted
    700 thousand
    Cost
    —
    Trend
    Worsening
    28.1

    Limited

  93. 93▲72

    Armenia-Azerbaijan Conflict

    Caucasus

    A resolved territorial war that produced the near-total displacement of a population.

    Deaths
    7 thousand
    (2020-2023)
    Impacted
    120 thousand
    Cost
    —
    Trend
    Improving
    22.1

    Limited

  94. 94▲72

    Snakebite Envenoming

    Global

    A neglected rural killer with an effective treatment that rarely reaches victims.

    Deaths
    100 thousand
    (per year)
    Impacted
    2.7 million
    Cost
    —
    Trend
    Steady
    21.7

    Limited

  95. 95▲73

    Riverine and Flash Flooding

    GlobalNews-derived

    Flash floods and mudflows washed away villages near the Nepal-China border, killing over 150 people and leaving many missing.

    Deaths
    157
    Impacted
    3.2 billion
    Cost
    $1.3 trillion
    Trend
    Worsening
    19.7

    Limited

  96. 96▲80

    Kumamoto Earthquake

    Kumamoto, JapanNews-derived

    A magnitude-6.8 earthquake in Kyushu killed at least 13 people, left others missing and displaced thousands as rescue operations continued.

    Deaths
    13
    Impacted
    93 thousand
    Cost
    —
    Trend
    Worsening
    13.4

    Limited

 
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